In the NFL Bettor’s Guide, football handicapper Sean Treppedi provides insights for betting on two key matchups. The Seattle Seahawks are favored by 6.5 points against the New York Giants, with Seattle boasting a strong offense led by Geno Smith. Meanwhile, the Arizona Cardinals are underdogs by 7.5 points against the San Francisco 49ers, despite a solid offense led by Kyler Murray and James Conner. Historical trends suggest that underdogs who lost by a large margin the week prior have a good chance of covering the spread.
The Giants may have won against Cleveland but should not be overvalued, especially against a strong Seattle team. The NFC West is making a strong case this season, with the Seahawks ranked fourth overall in DVOA. In contrast, the Giants are ranked 25th, with few standout players outside of Malik Nabers, who is dealing with a recent concussion.
As for the 49ers, although they had a good showing against New England, injuries to key players like George Kittle and Christian McCaffrey could be detrimental. Quarterback Brock Purdy, who has had success against Arizona, has not performed well when favored by four points or more in the past. Overall, Treppedi’s picks for this week are the Seahawks to cover the spread against the Giants and the Cardinals to cover against the 49ers.
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